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Non-Invasive Central Aortic Pressure Monitoring for Clinical Trials

Measuring central BP provides health care providers and patients additional information about the possibility of experiencing end-organ damage, cerebrovascular disease, cognitive impairment, and cardiovascular disease. Elevated central pressures have been associated with an increased risk of vascular events and cognitive impairment.

Monitoring central BP at home is anticipated to have the following potential benefits:

• Increase the effectiveness of management plans (lifestyle and medical) that are anticipated to positively impact brain health
• provide feedback directly to patients and further empower patients
• Improve the relationship between health care providers and patients
• Improve the ability of health care providers to evaluate complex interactions between comorbidities and drugs that can affect vascular physiology

Including a dual blood pressure monitoring system (measuring both central and brachial blood pressure) as part of patient care is anticipated to improve understanding of vascular physiology, add value in the determination of risk for cerebrovascular disease and cognitive impairment, and provide additional guidance for treatment decisions with the objective of improving long-term brain health.